{"id":756,"date":"2015-01-28T18:55:30","date_gmt":"2015-01-28T18:55:30","guid":{"rendered":"http:\/\/sites.rochester.edu\/larracuente\/?page_id=756"},"modified":"2019-02-03T19:36:06","modified_gmt":"2019-02-03T19:36:06","slug":"the-functional-and-evolutionary-genomics-of-satellite-dna","status":"publish","type":"page","link":"https:\/\/sites.rochester.edu\/larracuente\/the-functional-and-evolutionary-genomics-of-satellite-dna\/","title":{"rendered":"The functional and evolutionary genomics of satellite DNA"},"content":{"rendered":"

Satellite DNAs make up a large fraction of eukaryotic genomes and have important functions in chromosome pairing and segregation. The rapid evolution of satellite DNAs is a major force contributing to genome evolution across taxa and is implicated in genetic incompatibilities between species.<\/p>\n

\"LarracuentRspAAGAG\"<\/a>
Drosophila melanogaster mitotic chromosomes showing the locations of the Rsp (red) and AAGAG (green) satellites.<\/figcaption><\/figure>\n

We use genomic, molecular and cytological techniques to study the forces driving the rapid divergence at satellite repeats in Drosophila<\/em> populations and across Drosophila<\/em> species. By developing methods to quantify satellite repeats using next generation sequencing and other molecular approaches, we have the ability to study the dynamics of satellite DNA evolution on a fine time scale.<\/p>\n

The misregulation of satellite DNA is linked to genome instability, some cancers, and hybrid dysgenesis. We currently know little about the regulation of satellite DNA and the origin of satellite-derived RNAs. We use molecular, genomic and cytological approaches to study the expression and maintenance of satellite DNA across Drosophila<\/em> species.<\/p>\n

This work is supported by an NIH MIRA (NIGMS) award to AML.<\/p>\n","protected":false},"excerpt":{"rendered":"

Satellite DNAs make up a large fraction of eukaryotic genomes and have important functions in chromosome pairing and segregation. 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