{"id":4082,"date":"2017-08-01T23:26:02","date_gmt":"2017-08-01T23:26:02","guid":{"rendered":"https:\/\/sites.rochester.edu\/gsharma\/?page_id=4082"},"modified":"2017-10-14T11:51:40","modified_gmt":"2017-10-14T11:51:40","slug":"rnastructestim","status":"publish","type":"page","link":"https:\/\/sites.rochester.edu\/gsharma\/research\/medbioinformatics\/rnastructestim\/","title":{"rendered":"RNA Structure Estimation from Multiple Homologs"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-1842 alignleft\" src=\"https:\/\/sites.rochester.edu\/gsharma\/wp-content\/uploads\/2017\/05\/BioInfo-300x186.png\" alt=\"\" width=\"300\" height=\"186\" srcset=\"https:\/\/sites.rochester.edu\/gsharma\/wp-content\/uploads\/2017\/05\/BioInfo-300x186.png 300w, https:\/\/sites.rochester.edu\/gsharma\/wp-content\/uploads\/2017\/05\/BioInfo.png 400w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Nature encodes the functional structure of a (noncoding) RNA molecule as multiple alternative homologous sequences in different organisms. In our work, we seek to decode this common structure by exploiting this comparative information across the multiple homologs in combination with thermodynamic models for predicting secondary structure.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 14pt;\"><strong>Software<\/strong><\/span><\/p>\n<p>The tools developed in this work are distributed in open source format as part of the <a href=\"http:\/\/rna.urmc.rochester.edu\/RNAstructure.html\">RNA Structure package<\/a> from the Mathews lab.<\/p>\n<p><span style=\"font-size: 14pt;\"><strong>Selected Publications<\/strong><\/span><\/p>\n<p>[tplist tag=&#8221;962&#8243; template=&#8221;tp_template_2016&#8243; ]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature encodes the functional structure of a (noncoding) RNA molecule as multiple alternative homologous sequences in different organisms. In our work, we seek to decode this common structure by exploiting&hellip;<\/p>\n","protected":false},"author":22,"featured_media":0,"parent":1732,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width.php","meta":{"_acf_changed":false,"footnotes":"","_members_access_role":[],"_members_access_error":""},"class_list":["post-4082","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>RNA Structure Estimation from Multiple Homologs - Sharma Research Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.rochester.edu\/gsharma\/research\/medbioinformatics\/rnastructestim\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RNA Structure Estimation from Multiple Homologs - Sharma Research Group\" \/>\n<meta property=\"og:description\" content=\"Nature encodes the functional structure of a (noncoding) RNA molecule as multiple alternative homologous sequences in different organisms. 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